Advancing the Frontiers of Parkinson's Disease Research
Parkinson’s disease (PD) remains one of the most challenging neurodegenerative disorders to diagnose and monitor.
Conventional clinical assessments and imaging often miss the early molecular events driving disease onset, while overlapping symptoms with other synucleinopathies, such as dementia with Lewy bodies (DLB) and multiple system atrophy (MSA), further complicate diagnosis.
Alpha synuclein seed amplification assays (SAAs), including RT-QuIC (Real-Time Quaking-Induced Conversion), have emerged as transformative tools bridging this diagnostic gap.
By exploiting the prion-like seeding behavior of misfolded alpha synuclein, these assays detect trace amounts of pathogenic aggregates with exceptional sensitivity and specificity, enabling earlier and more accurate identification of disease-associated seeds.
Author's summary: Advancing Parkinson's research with alpha synuclein seed assays.
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