Open-source protein structure AI aims to match AlphaFold

Open-source protein structure AI aims to match AlphaFold

The developers of OpenFold3 have released an early version of the tool, which they hope will one day perform on par with DeepMind’s protein-structure model.

An AlphaFold3 model of a protein (blue) interacting with RNA (purple). Credit: Google DeepMind

Scientists today released a ‘sneak preview’ of a new open-source artificial intelligence (AI) model that predicts 3D structures of proteins, and say it is close to matching the performance of Google DeepMind’s revolutionary protein-folding AI AlphaFold3.

Author's summary: OpenFold3 aims to match AlphaFold performance.

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Nature Nature — 2025-10-28

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