NFL picks, predictions: 3 plus-money bets for Week 6

NFL Picks and Predictions for Week 6

The NFL season continues with a highly-anticipated slate of games in Week 6. Here are 3 plus-money bets to consider before kickoff.

By Spenser Davis, Published: Oct 12, 2025 · 8:30 AM EDT

Week 6 Predictions

Last week's NFL bold predictions went 2-1, resulting in a gain of +1.17 units overall. Since the start of Week 3, picks in this story are up 2.16 units.

3 Bold Predictions for Week 6

This week's predictions include fading the Colts offense, which may not be the wisest choice, but there is a case for doing so. Indianapolis is currently averaging 3.39 points per drive, which would be the most this century if they maintain this pace all season long.

Fading the Colts offense is perhaps not the wisest choice, but I think there’s a case for doing so here.

Autor's summary: NFL Week 6 predictions and picks.

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