Base Editing Corrects Mutations for Cardiac Disease in Mice
Researchers used base editing to correct a point mutation in the lamin A (LMNA) gene in mice, preventing skeletal and cardiac abnormalities and extending their lifespans.
Point mutations in the lamin A (LMNA) gene cause several human diseases, including congenital muscular dystrophy and premature aging, collectively known as laminopathies, which affect skeletal muscles and the heart.
While existing therapies can mitigate the symptoms of these conditions, there is no cure. Base-editing methods have recently emerged as tools for correcting point mutations without creating double-stranded breaks in DNA, making them a safer therapeutic strategy.
Base editing of LMNA-associated mutations that cause cardiac disease has remained unexplored.
Author's summary: Base editing corrects cardiac disease mutations in mice.
More News
- Male views on masculinity are gradually shifting — and that's good for their mental health
- 'Argentina gradually joins the great authoritarian wave sweeping the globe'
- Why shared ownership remains a vital tenure
- ICE Plans Cash Rewards for Private Bounty Hunters to Locate and Track Immigrants
- Caitlin Clark and Paige Bueckers will have star power challenged by "generational talent" in 2027
- Ethics rules didn't require Sheffield to disclose relationship
- The power of organising and how to win the outsourcing battle | Article | News | UNISON National